Theoretical approaches to identify the potent scaffold for human sirtuin1 activator: Bayesian modeling and density functional theory
Bayesian and pharmacophore modeling approaches were utilized to identify the fragments and critical chemical features of small molecules that enhance sirtuin1 (SIRT1) activity. Initially, 48 Bayesian models (BMs) were developed by exploring 12 different fingerprints (ECFC, ECFP, EPFC, EPFP, FPFC, FP...
| Main Authors: | , , , |
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| Format: | Journal Article |
| Published: |
Birkhaeuser Science
2014
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| Subjects: | |
| Online Access: | http://hdl.handle.net/20.500.11937/40389 |