Gelsolin induces colorectal tumor cell invasion via modulation of the urokinase-type plasminogen activator cascade

QR Code

Gelsolin induces colorectal tumor cell invasion via modulation of the urokinase-type plasminogen activator cascade

Gelsolin is a cytoskeletal protein which participates in actin filament dynamics and promotes cell motility and plasticity. Although initially regarded as a tumor suppressor, gelsolin expression in certain tumors correlates with poor prognosis and therapy-resistance. In vitro, gelsolin has anti-apop...

Full description

Bibliographic Details
Main Authors:	Zhuo, J., Tan, E., Yan, B., Tochhawng, L., Jayapal, M., Koh, S., Tay, H., Maciver, S., Hooi, S., Salto-Tellez, M., Kumar, Alan Prem, Goh, Y., Lim, Y., Yap, C.
Format:	Journal Article
Published:	Public Library of Science 2012
Online Access:	http://hdl.handle.net/20.500.11937/40322

Similar Items

Urokinase plasminogen activator receptor polymorphisms and airway remodelling in asthma
by: Ierodiakonou, Despo, et al.
Published: (2016)

Gelsolin-Cu/ZnSOD interaction alters intracellular reactive oxygen species levels to promote cancer cell invasion.
by: Tochhawng, L., et al.
Published: (2016)

Gelsolin-mediated activation of PI3K/Akt pathway is crucial for hepatocyte growth factor-induced cell scattering in gastric carcinoma
by: Huang, B., et al.
Published: (2016)

Airway and peripheral urokinase plasminogen activator receptor is elevated in asthma, and identiﬁes a severe, nonatopic subset of patients
by: Portelli, Michael A., et al.
Published: (2016)

The role and regulation of the urokinase receptor in asthma and COPD
by: Portelli, Michael A.
Published: (2013)

Production of urokinase by HT 1080 human kidney cell line
by: Roychoudhury, Pradip A., et al.
Published: (1999)

The expression of RUNX3 in colorectal cancer is associated with disease stage and patient outcome
by: Soong, R., et al.
Published: (2009)

Redox regulation of cancer cell migration and invasion
by: Tochhawng, L., et al.
Published: (2013)

Tissue plasminogen activator potently stimulates pleural effusion via a monocyte chemotactic protein-1-dependent mechanism
by: Lansley, S., et al.
Published: (2015)

CHIP/Stub1 functions as a tumor suppressor and represses NF-?B-mediated signaling in colorectal cancer
by: Wang, Y., et al.
Published: (2014)

Dysregulated repair in asthmatic paediatric airway epithelial cells: The role of plasminogen activator inhibitor-1
by: Stevens, P.T., et al.
Published: (2008)

Intracameral recombinant tissue plasminogen activator (rtPA) as the primary treatment for secondary pupillary block
by: Siti Noor Atikah AR,, et al.
Published: (2022)

Intracameral recombinant tissue plasminogen activator (rtPA) as the primary treatment for secondary pupillary block
by: AR, Siti Noor Atikah, et al.
Published: (2022)

Combination of VP3 and CD147-knockdown enhance apoptosis and tumor growth delay index in colorectal tumor allograft
by: Ismail, Ruzila, et al.
Published: (2016)

Immunomodulation by MYB is associated with tumor relapse in patients with early stage colorectal cancer
by: Millen, R., et al.
Published: (2016)

The prognostic value of the stem-like group in colorectal cancer using a panel of immunohistochemistry markers
by: Ong, C., et al.
Published: (2015)

Nimbolide-induced oxidative stress abrogates STAT3 signaling cascade and inhibits tumor growth in transgenic adenocarcinoma of mouse prostate model
by: Zhang, J., et al.
Published: (2016)

Gene expression analysis of the concomitant existence of lymphovascular and perineural invasion in colorectal cancer
by: Nadiah Abu,, et al.
Published: (2018)

Ascochlorin, an isoprenoid antibiotic inhibits growth and invasion of hepatocellular carcinoma by targeting STAT3 signaling cascade through the induction of PIAS3
by: Dai, X., et al.
Published: (2015)

Expression of sema4d and its receptor Plexin-b1 in invasive breast ductal Carcinoma in relation to Tumor angiogenesis and Tumor-associated macrophages
by: Seng,, Ch’ng Ewe
Published: (2012)

Tumor-infiltrating FOXP3+ T regulatory cells show strong prognostic significance in colorectal cancer
by: Salama, P., et al.
Published: (2009)

The association of Streptococcus bovis/gallolyticus with colorectal tumors : the nature and the underlying mechanisms of its etiological role.
by: Abdulamir, Ahmed Sahib, et al.
Published: (2011)

Application of fuzzy linear regression models for predicting tumor size of colorectal cancer in Malaysia's Hospital
by: Shafi, Muhammad Ammar
Published: (2015)

Isorhamnetin augments the anti-tumor effect of capeciatbine through the negative regulation of NF-?B signaling cascade in gastric cancer
by: Manu, K., et al.
Published: (2015)

Targeting PPARy signaling cascade for the prevention and treatment of prostate cancer
by: Sikka, S., et al.
Published: (2012)

Fructose-1,6-bisphosphate aldolase of Neisseria meningitidis binds human plasminogen via its C-terminal lysine residue
by: Shams, Fariza, et al.
Published: (2016)

Development of new non-invasive tests for colorectal cancer screening: The relevance of information on adenoma detection
by: Haug, U., et al.
Published: (2015)

Elucidation Of The Roles Of y-Synuclein In The Invasiveness and Survival Of Colorectal Cancer Cell Line, LS 174T
by: Wey, Goh Kai
Published: (2015)

Investigation Of The Role Of Cellular Prion Protein In The Invasiveness And Survival Of Ls 174t Colorectal Cancer Cells
by: Lee, Cornelius Chieng Kwang
Published: (2015)

Enhanced anti-tumor effect of pH-responsive dextrin nanogels delivering doxorubicin on colorectal cancer
by: Manchun, S., et al.
Published: (2015)

The interplay between p53 and p21 tumor suppressor proteins in the transformation of colorectal adenoma to carcinoma.
by: Abdulamir, Ahmed Sahib, et al.
Published: (2008)

Suppression of PKC-α attenuates TNF-α-evoked cerebral barrier breakdown via regulations of MMP-2 and plasminogen–plasmin system
by: Abdullah, Zuraidah, et al.
Published: (2016)

Investigation Of Molecular Mechanisms Underlying The Anti-Tumor And Anti-Angiogenic Activities Of Orthosiphon Stamineus Towards Colorectal Cancer
by: Al-Suede, Fouad Saleih Resq
Published: (2016)

The Potential Anti-Tumor Extract Of Ocimum Basilicum Lamiaceae Towards Colorectal Cancer Via The Angiogenesis Mechanistic Pathway
by: Al Deeb, Ibrahim Deeb Tawfiq
Published: (2021)

Prognostic significance of thymidylate synthase, dihydropyrimidine dehydrogenase and thymidine phosphorylase protein expression in colorectal cancer patients treated with or without 5-fluorouracil-based chemotherapy
by: Soong, R., et al.
Published: (2008)

Corrigendum on “Isorhamnetin augments the anti-tumor effect of capeciatbine through the negative regulation of NF-κB signaling cascade in gastric cancer” [Cancer Lett. 363 (1) (2015) 28–36]
by: Manu, K., et al.
Published: (2018)

Attenuation of urokinase activity during experimental ischaemia protects the cerebral barrier from damage through regulation of matrix metalloproteinase-2 and NAD(P)H oxidase
by: Rakkar, Kamini, et al.
Published: (2014)

Breast tumor diagnosis in digital mammograms
by: Yang Lim, Xiang, et al.
Published: (2019)

Polymorphism in the tumor necrosis factor alpha promoter region and its influence on colorectal cancer predisposition risk in Malaysian population
by: Mohd Aminudin, Mustapha, et al.
Published: (2011)

A hybrid of multiple linear regression clustering model with support vector machine for colorectal cancer tumor size prediction
by: Shafi, Muhammad Ammar, et al.
Published: (2019)