Binding mode analysis of dual inhibitors of human thymidylate synthase and dihydrofolate reductase as antitumour agents via molecular docking and DFT studies
Due to the diligence of inherent redundancy and robustness in many biological networks and pathways, multitarget inhibitors present a new prospect in the pharmaceutical industry for treatment of complex diseases. Nevertheless, to design multitarget inhibitors is concurrently a great challenge for me...
| Main Authors: | , |
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| Format: | Journal Article |
| Published: |
Taylor and Francis Ltd.
2015
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| Online Access: | http://hdl.handle.net/20.500.11937/3898 |