Insight the C-Site Pocket Conformational Changes Responsible for Sirtuin 2 Activity Using Molecular Dynamics Simulations

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Insight the C-Site Pocket Conformational Changes Responsible for Sirtuin 2 Activity Using Molecular Dynamics Simulations

Sirtuin belongs to a family of typical histone deacetylase which regulates the fundamental cellular biological processes including gene expression, genome stability, mitosis, nutrient metabolism, aging, mitochondrial function, and cell motility. Michael et. al. reported that B-site mutation (Q167A a...

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Bibliographic Details
Main Authors:	Sakkiah, Sugunadevi, Arooj, Mahreen, Ping Cao, Guang, Woo Lee, Keun
Format:	Journal Article
Published:	Public Library of Science 2013
Online Access:	http://hdl.handle.net/20.500.11937/3869

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