Insight the C-Site Pocket Conformational Changes Responsible for Sirtuin 2 Activity Using Molecular Dynamics Simulations
Sirtuin belongs to a family of typical histone deacetylase which regulates the fundamental cellular biological processes including gene expression, genome stability, mitosis, nutrient metabolism, aging, mitochondrial function, and cell motility. Michael et. al. reported that B-site mutation (Q167A a...
| Main Authors: | , , , |
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| Format: | Journal Article |
| Published: |
Public Library of Science
2013
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| Online Access: | http://hdl.handle.net/20.500.11937/3869 |