PHLDA1 expression marks the putative epithelial stem cells and contributes to intestinal tumorigenesis

PHLDA1 expression marks the putative epithelial stem cells and contributes to intestinal tumorigenesis

Studies employing mouse models have identified crypt base and position +4 cells as strong candidates for intestinal epithelial stem cells. Equivalent cell populations are thought to exist in the human intestine; however robust and specific protein markers are lacking. Here, we show that in the human...

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Bibliographic Details
Main Authors: Sakthianandeswaren, A., Christie, M., D'Andreti, C., Tsui, C., Jorissen, R., Li, S., Fleming, N., Gibbs, P., Lipton, L., Malaterre, J., Ramsay, R., Phesse, T., Ernst, M., Jeffery, R., Poulsom, R., Leedham, S., Segditsas, S., Tomlinson, I., Bernhard, O., Simpson, R., Walker, F., Faux, M., Church, N., Catimel, B., Flanagan, D., Vincan, Elizabeth, Sieber, O.
Format: Journal Article
Published: 2011
Online Access:http://hdl.handle.net/20.500.11937/38391

Internet

http://hdl.handle.net/20.500.11937/38391

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