IL-2/CD40-activated macrophages rescue age and tumor-induced T cell dysfunction in elderly mice

QR Code

IL-2/CD40-activated macrophages rescue age and tumor-induced T cell dysfunction in elderly mice

The role of macrophages and their interactions with T cells during aging is not well understood. We determined if activating elderly-derived macrophages could rescue age-related and tumor-induced T cell dysfunction. Healthy elderly (18–24 months) Balb/c contained significantly more splenic IL-10-sec...

Full description

Bibliographic Details
Main Authors:	Jackaman, Connie, Dye, Danielle, Nelson, Delia
Format:	Journal Article
Published:	Springer Netherlands 2014
Subjects:	T cell Immune restoration Elderly Macrophage Cancer immunotherapy Innate immunity
Online Access:	http://hdl.handle.net/20.500.11937/3766

Similar Items

Streptococcus uberis strains isolated from the bovine mammary gland evade immune recognition by mammary epithelial cells, but not of macrophages
by: Günther, Juliane, et al.
Published: (2016)

Targeting macrophages rescues age-related immune deficiencies in C57BL/6J geriatric mice
by: Jackaman, Connie, et al.
Published: (2013)

Are macrophages, myeloid derived suppressor cells and neutrophils mediators of local suppression in healthy and cancerous tissues in aging hosts?
by: Jackaman, Connie, et al.
Published: (2013)

Targeting macrophages rescues age and tumor-induced T cell dysfunction in elderly mice
by: Jackaman, Connie, et al.
Published: (2016)

Immune-instructive polymers for modulating macrophage phenotype
by: Alromaihi, Reem
Published: (2024)

Part A - PD-1/PD-L1 blockade in cancer immunotherapy/ Part B - Evaluation of PD-1/PD-L1 immune checkpoint inhibitors in a luciferase-reporter cell-based assay
by: Peredo Aguilar, Maria Azucena
Published: (2023)

Characterisation of the modulation of immune response to polymer implants using established and novel methods
by: Suvannapruk, Waraporn
Published: (2023)

Unbiased analysis of the impact of micropatterned biomaterials on macrophage behaviour provides insights beyond pre-defined polarisation states
by: Singh, Sonali, et al.
Published: (2017)

Intratumoral interleukin-2/agonist CD40 antibody drives CD4+ - independent resolution of treated-turmors and CD4+ -dependent systemic and memory responses
by: Jackaman, Connie, et al.
Published: (2012)

High resolution sequencing of hepatitis C virus reveals limited intra-hepatic compartmentalization in end-stage liver disease
by: Hedegaard, Ditte L., et al.
Published: (2017)

Investigating predation by the predatory bacterium Bdellovibrio bacteriovorus at the interface between predatory bacteria, pathogenic prey, and the host immune response
by: Clark, Callum
Published: (2023)

Integrin-mediated interactions control macrophage polarization in 3D hydrogels
by: Cha, Byung-Hyun, et al.
Published: (2017)

Inflammation and immunosurveillance in breast cancer
by: Mahmoud, Sahar
Published: (2011)

Injections of predatory bacteria work alongside host immune cells to treat Shigella infection in zebrafish larvae
by: Willis, Alexandra R., et al.
Published: (2016)

Oral vaccination with a rough attenuated mutant of S. Infantis increases post-wean weight gain and prevents clinical signs of salmonellosis in S. Typhimurium challenged pigs
by: Foster, Neil, et al.
Published: (2016)

Comparison of host innate immune response of human and porcine airway epithelial cells and anti-influenza exploitation
by: Yang, Jiayun
Published: (2021)

Influence of dietary oligosaccharides on the gut microbiome
by: Richards, Philip J.
Published: (2020)

Detecting anomalous process behaviour using second generation Artificial Immune Systems
by: Twycross, Jamie, et al.
Published: (2010)

Bat lung epithelial cells show greater host species-specific innate resistance than MDCK cells to human and avian influenza viruses
by: Slater, Tessa, et al.
Published: (2018)

The ecology of immune variation in wild house mice (Mus musculus domesticus)
by: Young, Stuart
Published: (2019)

The expression of HLA class I molecules and complement regulatory proteins in ovarian cancer
by: Rolland, Philip
Published: (2008)

Emerging Mechanisms of Physical Exercise Benefits in Adjuvant and Neoadjuvant Cancer Immunotherapy.
by: Casciano, Fabio, et al.
Published: (2024)

Immunogenicity of soluble enterovirus 71 recombinant VP1 protein in mice model
by: Mustafa, Suhaili
Published: (2017)

Mertk on tumor macrophages is a therapeutic target to prevent tumor recurrence following radiation therapy
by: Crittenden, Marka R., et al.
Published: (2016)

Transcriptome profile of the human endothelial cell response to high- and low-density infections of Candida albicans
by: Chong, Pei Pei, et al.
Published: (2010)

Immune Cells Function and Activation in Response to Carica Papaya L. Consumed by Healthy Individuals
by: Loh, Chiew Yee
Published: (2011)

Factors associated with adherence towards different vaccines of childhood immunization of under five children among mothers attending Klinik Kesihatan Seremban
by: Zainal Abidin, Zamzaireen
Published: (2017)

Oral immunization with cholera DNA vaccine employing microencapsulation delivery system
by: Nograles, Nadine Hayudini
Published: (2013)

An investigation into the drug disposition of the spleen organ as a potential immuno-therapeutic target
by: Inuwa, Patience G.
Published: (2024)

The impact of stroma and ionising radiation on the plasticity of dendritic cells and macrophages
by: Malecka, Anna A.
Published: (2018)

Evaluation of neutrophil extracellular trap production in pregnancy
by: Tarbox, Rebecca Clare
Published: (2017)

Cytokine gene expression patterns and immune responses to systemic Candida albicans infection in inbred mice.
by: Redwood, Alec J.
Published: (1997)

Immune responses to hepatitis C virus (HCV): investigation of the role of L-ficolin and anti-E1E2
by: Hamed, Mohamed R.
Published: (2009)

On the role of the AIS practitioner
by: Hart, Emma, et al.
Published: (2013)

Artificial immune systems
by: Aickelin, Uwe, et al.
Published: (2014)

Health literacy on childhood immunization among antenatal women and its associated factors in Seremban district, Negeri Sembilan
by: Mohamad Yusof, Nazatul Yusrina
Published: (2017)

Macrophage Depletion in Elderly Mice Improves Response to Tumor Immunotherapy, Increases Anti-tumor T Cell Activity and Reduces Treatment-Induced Cachexia
by: Duong, L., et al.
Published: (2018)

Regulation of ige-mediated mast cell degranulation in allergy by geranyl acetophenone
by: Tan, Ji Wei
Published: (2017)

The effects of the human innate pattern recognition receptor L-ficolin and its variants against Hepatitis C virus infection
by: Mason, Christopher Paul
Published: (2019)

Optimisation of microparticle formulations for IL-4 delivery for macrophage modulation in spinal cord injury
by: Stening, Jasmine Z.
Published: (2020)

Cannot write session to /tmp/vufind_sessions/sess_ca00d371s2do1jlkcjqhs62bta