Molecular dynamics simulation of the phosphorylation-induced conformational changes of a tau peptide fragment

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Molecular dynamics simulation of the phosphorylation-induced conformational changes of a tau peptide fragment

Aggregation of the microtubule associated protein tau (MAPT) within neurons of the brain is the leading cause of tauopathies such as Alzheimer's disease. MAPT is a phospho-protein that is selectively phosphorylated by a number of kinases in vivo to perform its biological function. However, it m...

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Bibliographic Details
Main Authors:	Lyons, Albert, Gandhi, Neha, Mancera, Ricardo
Format:	Journal Article
Published:	Wiley 2014
Subjects:	tau protein microtubule MAPT molecular dynamics phosphorylation
Online Access:	http://onlinelibrary.wiley.com/doi/10.1002/prot.24544/abstract http://hdl.handle.net/20.500.11937/37474

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