Molecular dynamics simulation of the phosphorylation-induced conformational changes of a tau peptide fragment
Aggregation of the microtubule associated protein tau (MAPT) within neurons of the brain is the leading cause of tauopathies such as Alzheimer's disease. MAPT is a phospho-protein that is selectively phosphorylated by a number of kinases in vivo to perform its biological function. However, it m...
| Main Authors: | , , |
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| Format: | Journal Article |
| Published: |
Wiley
2014
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| Subjects: | |
| Online Access: | http://onlinelibrary.wiley.com/doi/10.1002/prot.24544/abstract http://hdl.handle.net/20.500.11937/37474 |