Alzheimer's disease-related peptide PS2V plays ancient, conserved roles in suppression of the unfolded protein response under hypoxia and stimulation of ?-secretase activity

Alzheimer's disease-related peptide PS2V plays ancient, conserved roles in suppression of the unfolded protein response under hypoxia and stimulation of ?-secretase activity

The PRESENILIN1 and PRESENILIN2 genes encode structurally related proteases essential for ?-secretase activity. Of nearly 200 PRESENILIN mutations causing early onset, familial Alzheimer's disease (FAD) only the K115Efx10 mutation of PSEN2 causes truncation of the open reading frame. If transla...

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Bibliographic Details
Main Authors: Nik, S., Newman, M., Wilson, L., Ebrahimie, E., Wells, S., Musgrave, I., Verdile, Giuseppe, Martins, R., Lardelli, M.
Format: Journal Article
Published: Oxford University Press 2015
Online Access:http://hdl.handle.net/20.500.11937/37415

Internet

http://hdl.handle.net/20.500.11937/37415

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