Lifelong exercise and locally produced insulin-like growth factor-1 (IGF-1) have a modest influence on reducing age-related muscle wasting in mice

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Lifelong exercise and locally produced insulin-like growth factor-1 (IGF-1) have a modest influence on reducing age-related muscle wasting in mice

The age-related loss of skeletal muscle mass and function is termed sarcopenia and has been attributed to a decline in concentrations of insulin-like growth factor-1 (IGF-1). We hypothesized that constitutively expressed IGF-1 within skeletal muscles with or without exercise would prevent sarcopenia...

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Bibliographic Details
Main Authors:	McMahon, C., Chai, R., Crabb, Hannah, Watson, T., Matthews, K., Sheard, P., Soffe, Z., Grounds, M., Shavlakadze, T.
Format:	Journal Article
Published:	Wiley-Blackwell 2014
Subjects:	running wheels IGF-1 endurance exercise skeletal muscle Sarcopenia aging
Online Access:	http://hdl.handle.net/20.500.11937/3730

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