Lifelong exercise and locally produced insulin-like growth factor-1 (IGF-1) have a modest influence on reducing age-related muscle wasting in mice

Lifelong exercise and locally produced insulin-like growth factor-1 (IGF-1) have a modest influence on reducing age-related muscle wasting in mice

The age-related loss of skeletal muscle mass and function is termed sarcopenia and has been attributed to a decline in concentrations of insulin-like growth factor-1 (IGF-1). We hypothesized that constitutively expressed IGF-1 within skeletal muscles with or without exercise would prevent sarcopenia...

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Bibliographic Details
Main Authors: McMahon, C., Chai, R., Crabb, Hannah, Watson, T., Matthews, K., Sheard, P., Soffe, Z., Grounds, M., Shavlakadze, T.
Format: Journal Article
Published: Wiley-Blackwell 2014
Subjects:
running wheels
IGF-1
endurance exercise
skeletal muscle
Sarcopenia
aging
Online Access:http://hdl.handle.net/20.500.11937/3730

Internet

http://hdl.handle.net/20.500.11937/3730

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