A single nucleotide polymorphism in the CYP4F2 but not CYP4A11 gene is associated with increased 20-HETE excretion and blood pressure

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A single nucleotide polymorphism in the CYP4F2 but not CYP4A11 gene is associated with increased 20-HETE excretion and blood pressure

Arachidonic acid is a major fatty acid that can be metabolized by the cytochrome P450 enzyme to a number of bioactive eicosanoids. A major metabolite of this oxidation is 20-hydroxyeicosatetraenoic acid, which acts as a potent vasoconstrictor. However, in the kidney, its vasoconstrictor actions can...

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Bibliographic Details
Main Authors:	Ward, Natalie, Tsai, I., Barden, A., Van Bockxmeer, F., Puddey, I., Hodgson, J., Croft, K.
Format:	Journal Article
Published:	American Heart Association 2008
Online Access:	http://hdl.handle.net/20.500.11937/37067

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