A single nucleotide polymorphism in the CYP4F2 but not CYP4A11 gene is associated with increased 20-HETE excretion and blood pressure
Arachidonic acid is a major fatty acid that can be metabolized by the cytochrome P450 enzyme to a number of bioactive eicosanoids. A major metabolite of this oxidation is 20-hydroxyeicosatetraenoic acid, which acts as a potent vasoconstrictor. However, in the kidney, its vasoconstrictor actions can...
| Main Authors: | , , , , , , |
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| Format: | Journal Article |
| Published: |
American Heart Association
2008
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| Online Access: | http://hdl.handle.net/20.500.11937/37067 |