Analysis of selective metal-salt-induced endotoxin precipitation in plasmid DNA purification using improved limulus amoebocyte lysate assay and central composite design

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Analysis of selective metal-salt-induced endotoxin precipitation in plasmid DNA purification using improved limulus amoebocyte lysate assay and central composite design

Recent advancements in plasmid DNA (pDNA) production involve the development of innovative and cost-effective methods as well as reduced number of unit operations. This study investigates the feasibilities of using a metal salt to selectively remove endotoxins from clarified cell lysates containing...

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Bibliographic Details
Main Authors:	Ongkudon, C., Danquah, Michael
Format:	Journal Article
Published:	American Chemical Society 2011
Online Access:	http://hdl.handle.net/20.500.11937/36784

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