The significance of 2-furyl ring substitution with a 2-(para-substituted) aryl group in a new series of pyrazolo-triazolo-pyrimidines as potent and highly selective hA3 adenosine receptors antagonists: new insights into structure-affinity relationship and receptor-antagonist recognition

The significance of 2-furyl ring substitution with a 2-(para-substituted) aryl group in a new series of pyrazolo-triazolo-pyrimidines as potent and highly selective hA3 adenosine receptors antagonists: new insights into structure-affinity relationship and receptor-antagonist recognition

Among the heterocyclic structures identified as potent human A3 (hA3) adenosine receptor’s antagonists, we have demonstrated that the new pyrazolo-triazolo-pyrimidines, bearing an aryl group in replacement of the C2-furyl ring, not only confer a good pharmacological profile (with significantly enhan...

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Bibliographic Details
Main Authors: Cheong, S., Dolzhenko, A., Kachler, S., Paoletta, S., Federico, S., Cacciari, B., Dolzhenko, Anton, Klotz, K., Moro, S., Spalluto, G., Pastorin, G.
Format: Journal Article
Published: ACS Publications 2010
Subjects:
drug-receptor interactions
triazoles
adenosine receptor antagonists
molecular modeling
pyrimidines
pyrazoles
Online Access:http://hdl.handle.net/20.500.11937/36735

Internet

http://hdl.handle.net/20.500.11937/36735

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