An anthraquinone derivative, emodin sensitizes hepatocellular carcinoma cells to TRAIL induced apoptosis through the induction of death receptors and downregulation of cell survival proteins

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An anthraquinone derivative, emodin sensitizes hepatocellular carcinoma cells to TRAIL induced apoptosis through the induction of death receptors and downregulation of cell survival proteins

Recombinant tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is currently under clinical trials for cancer, however many tumor cells, including hepatocellular carcinoma (HCC) develop resistance to TRAIL-induced apoptosis. Hence, novel agents that can alleviate TRAIL-induced resistance...

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Bibliographic Details
Main Authors:	Subramaniam, Aruljothi, Loo, Ser, Rajendran, P., Manu, K., Permul, E., Li, F., Shanmugam, M., Siveen, K., Park, J., Ahn, K., Hui, K., Kumar, Alan Prem, Sethi, G.
Format:	Journal Article
Published:	Springer 2013
Subjects:	TRAIL DR5 DR4 Apoptosis Emodin CHOP HCC
Online Access:	http://hdl.handle.net/20.500.11937/35723

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