An anthraquinone derivative, emodin sensitizes hepatocellular carcinoma cells to TRAIL induced apoptosis through the induction of death receptors and downregulation of cell survival proteins

An anthraquinone derivative, emodin sensitizes hepatocellular carcinoma cells to TRAIL induced apoptosis through the induction of death receptors and downregulation of cell survival proteins

Recombinant tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is currently under clinical trials for cancer, however many tumor cells, including hepatocellular carcinoma (HCC) develop resistance to TRAIL-induced apoptosis. Hence, novel agents that can alleviate TRAIL-induced resistance...

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Bibliographic Details
Main Authors: Subramaniam, Aruljothi, Loo, Ser, Rajendran, P., Manu, K., Permul, E., Li, F., Shanmugam, M., Siveen, K., Park, J., Ahn, K., Hui, K., Kumar, Alan Prem, Sethi, G.
Format: Journal Article
Published: Springer 2013
Subjects:
TRAIL
DR5
DR4
Apoptosis
Emodin
CHOP
HCC
Online Access:http://hdl.handle.net/20.500.11937/35723

Internet

http://hdl.handle.net/20.500.11937/35723

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