Arachidonic acid actions on functional integrity and attenuation of the negative effects of palmitic acid in a clonal pancreatic ß-cell line

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Arachidonic acid actions on functional integrity and attenuation of the negative effects of palmitic acid in a clonal pancreatic ß-cell line

Chronic exposure of pancreatic β-cells to saturated non-esterified fatty acids can lead to inhibition of insulin secretion and apoptosis. Several previous studies have demonstrated that saturated fatty acids such as PA (palmitic acid) are detrimental to β-cell function compared with unsaturated fatt...

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Bibliographic Details
Main Authors:	Keane, D., Takahashi, H., Dhayal, S., Morgan, N., Curi, R., Newsholme, Philip
Format:	Journal Article
Published:	Portland Press Ltd. 2011
Subjects:	pancreatic β-cell Type 2 diabetes mellitus reactive oxygen species arachidonic acid lipotoxicity palmitic acid
Online Access:	http://hdl.handle.net/20.500.11937/3568

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