Synthesis and biological evaluation of novel hybrids of highly potent and selective a4ß2-Nicotinic acetylcholine receptor (nAChR) partial agonists

Synthesis and biological evaluation of novel hybrids of highly potent and selective a4ß2-Nicotinic acetylcholine receptor (nAChR) partial agonists

© 2016 Elsevier Masson SASWe previously reported the cyclopropylpyridine and isoxazolylpyridine ether scaffolds to be versatile building blocks for creating potent a4ß2 nicotinic acetylcholine receptor (nAChR) partial agonists with excellent selectivity over the a3ß4 subtype. In our continued effort...

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Bibliographic Details
Main Authors: Zhang, H., Eaton, J., Fedolak, A., Gunosewoyo, Hendra, Onajole, O., Brunner, D., Lukas, R., Yu, L., Kozikowski, A.
Format: Journal Article
Published: Elsevier Masson 2016
Online Access:http://hdl.handle.net/20.500.11937/35620

Internet

http://hdl.handle.net/20.500.11937/35620

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