Structural analogs of huperzine A improve survival in guinea pigs exposed to soman

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Structural analogs of huperzine A improve survival in guinea pigs exposed to soman

Chemical warfare nerve agents such as soman exert their toxic effects through an irreversible inhibition of acetylcholinesterase (AChE) and subsequently glutamatergic function, leading to uncontrolled seizures. The natural alkaloid (-)-huperzine A is a potent inhibitor of AChE and has been demonstra...

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Bibliographic Details
Main Authors:	Gunosewoyo, Hendra, Tipparaju, S., Pieroni, M., Wang, Y., Doctor, B., Nambiar, M., Kozikowski, A.
Format:	Journal Article
Published:	Pergamon 2013
Subjects:	Acetylcholinesterase Soman Neuroprotection Huperzine A analogs Nerve agent
Online Access:	http://hdl.handle.net/20.500.11937/35164

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