Structural analogs of huperzine A improve survival in guinea pigs exposed to soman
Chemical warfare nerve agents such as soman exert their toxic effects through an irreversible inhibition of acetylcholinesterase (AChE) and subsequently glutamatergic function, leading to uncontrolled seizures. The natural alkaloid (-)-huperzine A is a potent inhibitor of AChE and has been demonstra...
| Main Authors: | , , , , , , |
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| Format: | Journal Article |
| Published: |
Pergamon
2013
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| Subjects: | |
| Online Access: | http://hdl.handle.net/20.500.11937/35164 |