Structural analogs of huperzine A improve survival in guinea pigs exposed to soman
Chemical warfare nerve agents such as soman exert their toxic effects through an irreversible inhibition of acetylcholinesterase (AChE) and subsequently glutamatergic function, leading to uncontrolled seizures. The natural alkaloid (-)-huperzine A is a potent inhibitor of AChE and has been demonstra...
| Main Authors: | , , , , , , |
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| Format: | Journal Article |
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Pergamon
2013
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| Online Access: | http://hdl.handle.net/20.500.11937/35164 |
| _version_ | 1848754421399289856 |
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| author | Gunosewoyo, Hendra Tipparaju, S. Pieroni, M. Wang, Y. Doctor, B. Nambiar, M. Kozikowski, A. |
| author_facet | Gunosewoyo, Hendra Tipparaju, S. Pieroni, M. Wang, Y. Doctor, B. Nambiar, M. Kozikowski, A. |
| author_sort | Gunosewoyo, Hendra |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Chemical warfare nerve agents such as soman exert their toxic effects through an irreversible inhibition of acetylcholinesterase (AChE) and subsequently glutamatergic function, leading to uncontrolled seizures. The natural alkaloid (-)-huperzine A is a potent inhibitor of AChE and has been demonstrated to exert neuroprotection at an appropriate dose. It is hypothesized that analogs of both (+)- and (-)-huperzine A with an improved ability to interact with NMDA receptors together with reduced AChE inhibition will exhibit more effective neuroprotection against nerve agents. In this manuscript, the tested huperzine A analogs 2 and 3 were demonstrated to improve survival of guinea pigs exposed to soman at either 1.2 or 2 × LD50. |
| first_indexed | 2025-11-14T08:40:08Z |
| format | Journal Article |
| id | curtin-20.500.11937-35164 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T08:40:08Z |
| publishDate | 2013 |
| publisher | Pergamon |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-351642017-09-13T15:32:25Z Structural analogs of huperzine A improve survival in guinea pigs exposed to soman Gunosewoyo, Hendra Tipparaju, S. Pieroni, M. Wang, Y. Doctor, B. Nambiar, M. Kozikowski, A. Acetylcholinesterase Soman Neuroprotection Huperzine A analogs Nerve agent Chemical warfare nerve agents such as soman exert their toxic effects through an irreversible inhibition of acetylcholinesterase (AChE) and subsequently glutamatergic function, leading to uncontrolled seizures. The natural alkaloid (-)-huperzine A is a potent inhibitor of AChE and has been demonstrated to exert neuroprotection at an appropriate dose. It is hypothesized that analogs of both (+)- and (-)-huperzine A with an improved ability to interact with NMDA receptors together with reduced AChE inhibition will exhibit more effective neuroprotection against nerve agents. In this manuscript, the tested huperzine A analogs 2 and 3 were demonstrated to improve survival of guinea pigs exposed to soman at either 1.2 or 2 × LD50. 2013 Journal Article http://hdl.handle.net/20.500.11937/35164 10.1016/j.bmcl.2012.11.083 Pergamon restricted |
| spellingShingle | Acetylcholinesterase Soman Neuroprotection Huperzine A analogs Nerve agent Gunosewoyo, Hendra Tipparaju, S. Pieroni, M. Wang, Y. Doctor, B. Nambiar, M. Kozikowski, A. Structural analogs of huperzine A improve survival in guinea pigs exposed to soman |
| title | Structural analogs of huperzine A improve survival in guinea pigs exposed to soman |
| title_full | Structural analogs of huperzine A improve survival in guinea pigs exposed to soman |
| title_fullStr | Structural analogs of huperzine A improve survival in guinea pigs exposed to soman |
| title_full_unstemmed | Structural analogs of huperzine A improve survival in guinea pigs exposed to soman |
| title_short | Structural analogs of huperzine A improve survival in guinea pigs exposed to soman |
| title_sort | structural analogs of huperzine a improve survival in guinea pigs exposed to soman |
| topic | Acetylcholinesterase Soman Neuroprotection Huperzine A analogs Nerve agent |
| url | http://hdl.handle.net/20.500.11937/35164 |