CD4 + T-cell deficiency in HIV patients responding to antiretroviral therapy is associated with increased expression of interferon-stimulated genes in CD4 + T cells
Most patients with human immunodeficiency virus (HIV) who remain CD4 + T-cell deficient on antiretroviral therapy (ART) exhibit marked immune activation. As CD4 + T-cell activation may be mediated by microbial translocation or interferon-alpha (IFN-a), we examined these factors in HIV patients with...
| Main Authors: | , , , , , , , , , , |
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| Format: | Journal Article |
| Published: |
2011
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| Online Access: | http://hdl.handle.net/20.500.11937/3445 |
| _version_ | 1848744234033610752 |
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| author | Fernandez, S. Tanaskovic, S. Helbig, K. Rajasuriar, R. Kramski, M. Murray, J. Beard, M. Purcell, D. Lewin, S. Price, Patricia French, M. |
| author_facet | Fernandez, S. Tanaskovic, S. Helbig, K. Rajasuriar, R. Kramski, M. Murray, J. Beard, M. Purcell, D. Lewin, S. Price, Patricia French, M. |
| author_sort | Fernandez, S. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Most patients with human immunodeficiency virus (HIV) who remain CD4 + T-cell deficient on antiretroviral therapy (ART) exhibit marked immune activation. As CD4 + T-cell activation may be mediated by microbial translocation or interferon-alpha (IFN-a), we examined these factors in HIV patients with good or poor CD4 + T-cell recovery on long-term ART. Messenger RNA levels for 3 interferon-stimulated genes were increased in CD4 + T cells of patients with poor CD4 + T-cell recovery, whereas levels in patients with good recovery did not differ from those in healthy controls. Poor CD4 + T-cell recovery was also associated with CD4 + T-cell expression of markers of activation, senescence, and apoptosis, and with increased serum levels of the lipopolysaccharide receptor and soluble CD14, but these were not significantly correlated with expression of the interferon-stimulated genes. Therefore, CD4 + T-cell recovery may be adversely affected by the effects of IFN-a, which may be amenable to therapeutic intervention. © 2011 The Author. |
| first_indexed | 2025-11-14T05:58:13Z |
| format | Journal Article |
| id | curtin-20.500.11937-3445 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T05:58:13Z |
| publishDate | 2011 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-34452017-09-13T14:43:26Z CD4 + T-cell deficiency in HIV patients responding to antiretroviral therapy is associated with increased expression of interferon-stimulated genes in CD4 + T cells Fernandez, S. Tanaskovic, S. Helbig, K. Rajasuriar, R. Kramski, M. Murray, J. Beard, M. Purcell, D. Lewin, S. Price, Patricia French, M. Most patients with human immunodeficiency virus (HIV) who remain CD4 + T-cell deficient on antiretroviral therapy (ART) exhibit marked immune activation. As CD4 + T-cell activation may be mediated by microbial translocation or interferon-alpha (IFN-a), we examined these factors in HIV patients with good or poor CD4 + T-cell recovery on long-term ART. Messenger RNA levels for 3 interferon-stimulated genes were increased in CD4 + T cells of patients with poor CD4 + T-cell recovery, whereas levels in patients with good recovery did not differ from those in healthy controls. Poor CD4 + T-cell recovery was also associated with CD4 + T-cell expression of markers of activation, senescence, and apoptosis, and with increased serum levels of the lipopolysaccharide receptor and soluble CD14, but these were not significantly correlated with expression of the interferon-stimulated genes. Therefore, CD4 + T-cell recovery may be adversely affected by the effects of IFN-a, which may be amenable to therapeutic intervention. © 2011 The Author. 2011 Journal Article http://hdl.handle.net/20.500.11937/3445 10.1093/infdis/jir659 unknown |
| spellingShingle | Fernandez, S. Tanaskovic, S. Helbig, K. Rajasuriar, R. Kramski, M. Murray, J. Beard, M. Purcell, D. Lewin, S. Price, Patricia French, M. CD4 + T-cell deficiency in HIV patients responding to antiretroviral therapy is associated with increased expression of interferon-stimulated genes in CD4 + T cells |
| title | CD4 + T-cell deficiency in HIV patients responding to antiretroviral therapy is associated with increased expression of interferon-stimulated genes in CD4 + T cells |
| title_full | CD4 + T-cell deficiency in HIV patients responding to antiretroviral therapy is associated with increased expression of interferon-stimulated genes in CD4 + T cells |
| title_fullStr | CD4 + T-cell deficiency in HIV patients responding to antiretroviral therapy is associated with increased expression of interferon-stimulated genes in CD4 + T cells |
| title_full_unstemmed | CD4 + T-cell deficiency in HIV patients responding to antiretroviral therapy is associated with increased expression of interferon-stimulated genes in CD4 + T cells |
| title_short | CD4 + T-cell deficiency in HIV patients responding to antiretroviral therapy is associated with increased expression of interferon-stimulated genes in CD4 + T cells |
| title_sort | cd4 + t-cell deficiency in hiv patients responding to antiretroviral therapy is associated with increased expression of interferon-stimulated genes in cd4 + t cells |
| url | http://hdl.handle.net/20.500.11937/3445 |