Docking of carbohydrates into protein binding sites
Structures of protein–carbohydrate complexes can be investigated experimentally by x-ray crystallography or nuclear magnetic resonance (NMR) (Chapters 1 and 2). However, the crystallization of these complexes is often complicated by the inherent flexibility of carbohydrates, whereas NMR is more appr...
| Main Authors: | , , |
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| Format: | Book Chapter |
| Published: |
CRC Press
2012
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| Online Access: | http://hdl.handle.net/20.500.11937/34332 |
| _version_ | 1848754194130927616 |
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| author | Agostino, Mark Ramsland, Paul Yuriev, E. |
| author_facet | Agostino, Mark Ramsland, Paul Yuriev, E. |
| author_sort | Agostino, Mark |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Structures of protein–carbohydrate complexes can be investigated experimentally by x-ray crystallography or nuclear magnetic resonance (NMR) (Chapters 1 and 2). However, the crystallization of these complexes is often complicated by the inherent flexibility of carbohydrates, whereas NMR is more appropriate for the determination of conformation of bound carbohydrates rather than the nature of the interactions occurring with a protein. Computational molecular modeling techniques offer attractive alternatives for the study of protein–carbohydrate interactions. These techniques have been widely used in conformational studies of carbohydrates, as well as in the investigation of carbohydrate–protein recognition. Notably, molecular dock¬ing can provide insight into protein–ligand interactions in systems that are difficult to study experimentally. |
| first_indexed | 2025-11-14T08:36:32Z |
| format | Book Chapter |
| id | curtin-20.500.11937-34332 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T08:36:32Z |
| publishDate | 2012 |
| publisher | CRC Press |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-343322017-01-30T13:42:41Z Docking of carbohydrates into protein binding sites Agostino, Mark Ramsland, Paul Yuriev, E. Structures of protein–carbohydrate complexes can be investigated experimentally by x-ray crystallography or nuclear magnetic resonance (NMR) (Chapters 1 and 2). However, the crystallization of these complexes is often complicated by the inherent flexibility of carbohydrates, whereas NMR is more appropriate for the determination of conformation of bound carbohydrates rather than the nature of the interactions occurring with a protein. Computational molecular modeling techniques offer attractive alternatives for the study of protein–carbohydrate interactions. These techniques have been widely used in conformational studies of carbohydrates, as well as in the investigation of carbohydrate–protein recognition. Notably, molecular dock¬ing can provide insight into protein–ligand interactions in systems that are difficult to study experimentally. 2012 Book Chapter http://hdl.handle.net/20.500.11937/34332 CRC Press restricted |
| spellingShingle | Agostino, Mark Ramsland, Paul Yuriev, E. Docking of carbohydrates into protein binding sites |
| title | Docking of carbohydrates into protein binding sites |
| title_full | Docking of carbohydrates into protein binding sites |
| title_fullStr | Docking of carbohydrates into protein binding sites |
| title_full_unstemmed | Docking of carbohydrates into protein binding sites |
| title_short | Docking of carbohydrates into protein binding sites |
| title_sort | docking of carbohydrates into protein binding sites |
| url | http://hdl.handle.net/20.500.11937/34332 |