Blood-brain barrier dysfunction developed during normal aging is associated with inflammation and loss of tight junctions but not with leukocyte recruitment
Background: Functional loss of blood–brain barrier (BBB) is suggested to be pivotal to pathogenesis and pathology of vascular-based neurodegenerative disorders such as Alzheimer’s disease. We recently reported in wild-type mice maintained on standard diets, progressive deterioration of capillary fun...
| Main Authors: | , , , , , , , |
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| Format: | Journal Article |
| Published: |
BioMed Central Ltd.
2015
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| Online Access: | http://hdl.handle.net/20.500.11937/3264 |