PI3K-C2γ is a Rab5 effector selectively controlling endosomal Akt2 activation downstream of insulin signalling

PI3K-C2γ is a Rab5 effector selectively controlling endosomal Akt2 activation downstream of insulin signalling

In the liver, insulin-mediated activation of the phosphatidylinositol 3-kinase (PI3K)/Akt pathway is at the core of metabolic control. Multiple PI3K and Akt isoenzymes are found in hepatocytes and whether isoform-selective interplays exist is currently unclear. Here we report that insulin signalling...

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Bibliographic Details
Main Authors: Braccini, L., Ciraolo, E., Campa, C., Perino, A., Longo, D., Tibolla, G., Pregnolato, M., Cao, Y., Tassone, B., Damilano, F., Laffargue, M., Calautti, E., Falasca, Marco, Norata, G., Backer, J., Hirsch, E.
Format: Journal Article
Published: Nature Publishing Group 2015
Online Access:http://hdl.handle.net/20.500.11937/32480

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http://hdl.handle.net/20.500.11937/32480

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