Evidence for and against a pathogenic role for reduced γ-secretase activity in familial Alzheimer’s disease

QR Code

Evidence for and against a pathogenic role for reduced γ-secretase activity in familial Alzheimer’s disease

The majority of mutations causing familial Alzheimer’s disease (fAD) have been found in the gene PRESENILIN1 (PSEN1 ) with additional mutations in the related gene PRESENILIN2 (PSEN2 ). The best characterized function of PRESENILIN (PSEN) proteins is in γ-secretase enzyme activity. One substrate of...

Full description

Bibliographic Details
Main Authors:	Verdile, Giuseppe, Jayne, T., Newman, M., Sutherland, G., Munch, G., Musgrave, I., Moussavi Nik, H., Lardelli, M.
Format:	Journal Article
Published:	IOS Press 2016
Online Access:	http://hdl.handle.net/20.500.11937/32300

Similar Items

Alzheimer's disease-related peptide PS2V plays ancient, conserved roles in suppression of the unfolded protein response under hypoxia and stimulation of ?-secretase activity
by: Nik, S., et al.
Published: (2015)

The structure and function of Alzheimer's gamma secretase enzyme complex
by: Krishnaswamy, S., et al.
Published: (2009)

Dysregulation of neuronal iron homeostasis as an alternative unifying effect of mutations causing familial Alzheimer's disease
by: Lumsden, A., et al.
Published: (2018)

γ-secretase inhibitors and modulators induce distinct conformational changes in the active sites of γ-secretase and signal peptide peptidase
by: Gertsik, Natalya, et al.
Published: (2015)

Zebrafish as a tool in Alzheimer's disease research
by: Newman, M., et al.
Published: (2011)

Models of Alzheimer’s Disease
by: Chen, M., et al.
Published: (2014)

Inflammation in Alzheimer's Disease, and Prevention with Antioxidants and Phenolic Compounds – What Are the Most Promising Candidates?
by: Sharman, M., et al.
Published: (2019)

Animal Models of Alzheimer's Disease
by: Newman, M., et al.
Published: (2017)

Efficient production of a mature and functional gamma secretase protease
by: Khan, I., et al.
Published: (2018)

Molecular Genetics of Alzheimer's Disease
by: Verdile, Giuseppe, et al.
Published: (2009)

The Guinea Pig as a Model for Sporadic Alzheimer’s Disease (AD): The Impact of Cholesterol Intake on Expression of AD-Related Genes
by: Sharman, Matthew, et al.
Published: (2013)

Detection of active site conformation changes of gamma-secretase, a key enzyme associated with Alzheimer disease, with small molecules
by: Gertsik, Natalya, et al.
Published: (2016)

The Role of Luteinizing Hormone in Alzheimer’s Disease
by: Barron, A., et al.
Published: (2010)

The role of gonadotoprins in Alzheimer’s disease: potential neurodegenerative mechanisms
by: Barron, A., et al.
Published: (2006)

The Role of Presenilin and its Interacting Proteins in the Biogenesis of Alzheimer’s Beta Amyloid
by: Verdile, Giuseppe, et al.
Published: (2007)

Reproductive Hormones Modulate Oxidative Stress in Alzheimer’s Disease
by: Barron, A., et al.
Published: (2006)

The Link Between Diabetes, Glucose Control, and Alzheimer's Disease and Neurodegenerative Diseases
by: Verdile, Giuseppe, et al.
Published: (2019)

Cholesterol metabolism and transport in the pathogenesis of Alzheimer's disease
by: Martins, I.j, et al.
Published: (2009)

Assessing genetic overlap of Alzheimer’s disease with type 2 diabetes
by: Adewuyi, Emmanuel, et al.
Published: (2025)

Differential, dominant activation and inhibition of notch signalling and APP cleavage by truncations of PSEN1 in human disease deficits
by: Newman, M., et al.
Published: (2014)

Immunization in Alzheimer’s disease: Naïve hope or realistic clinical potential?
by: Foster, Jonathan, et al.
Published: (2009)

Independent and cooperative action of Psen2 with Psen1 in zebrafish embryos
by: Nornes, S., et al.
Published: (2009)

Novel non-peptide β-secretase inhibitors derived from structure-based virtual screening and bioassay
by: Xu, W., et al.
Published: (2009)

A zebrafish melanophore model of amyloidß toxicity
by: Newman, M., et al.
Published: (2010)

The dynamics of CD147 in Alzheimer's disease development and pathology
by: Kanyenda, L., et al.
Published: (2011)

Research criteria for the diagnosis of Alzheimer’s disease: genetic risk factors, blood biomarkers and olfactory dysfunction
by: Foster, Jonathan, et al.
Published: (2008)

Hypoxia alters expression of Zebrafish Microtubule-associated protein Tau (mapta, maptb) gene transcripts
by: Nik, M., et al.
Published: (2014)

Effect of chronic hCG administration on Alzheimer's-related cognition and Aß accumulation in PS1KI mice
by: Barron, A., et al.
Published: (2010)

Examining the potential clinical value of curcumin in the prevention and diagnosis of Alzheimer’s disease
by: Goozee, K., et al.
Published: (2015)

Identification of a sub-micromolar, non-peptide inhibitor of β-secretase with low neural cytotoxicity through in silico screening
by: Xu, W., et al.
Published: (2010)

Modulation of the amyloidogenic pathway by a novel β-secretase inhibitor (F70hab16) from Malaysian Endophyte Cytospora Rhizophorae, in murine models for alzheimer’s disease / Richard Muhammad Johari James
by: James, Richard Muhammad Johari
Published: (2014)

Modulation of the amyloidogenic pathway by a Novel β-secretase inhibitor (F70HAB16) from Malaysian endophyte cytospora rhizophorae, in murine models for alzheimer’s disease / Richard Muhammad Johari James
by: Muhammad Johari James, Richard
Published: (2014)

Clearing the amyloid in Alzheimer's: progress towards earlier diagnosis and effective treatments - an update for clinicians.
by: Asih, P., et al.
Published: (2014)

Multiple Mechanisms Linking Type 2 Diabetes and Alzheimer's Disease: Testosterone as a Modifier
by: Asih, P., et al.
Published: (2017)

Clearance mechanisms of Alzheimer’s amyloid-b peptide: implications for therapeutic design and diagnostic tests
by: Bates, K., et al.
Published: (2009)

Amyloid-ß and islet amyloid pathologies link Alzheimer disease and type 2 diabetes in a transgenic model.
by: Wijesekara, N., et al.
Published: (2017)

Cognition and beta-amyloid in preclinical Alzheimer's disease: Data from the AIBL study
by: Pike, K., et al.
Published: (2011)

Expression of gamma secretase and notch signalling pathway in TS1CJE mouse model of down syndrome
by: Md Yusof, Hadri Hadi
Published: (2017)

Inflammation and oxidative stress: the molecular connectivity between insulin resistance, obesity, and Alzheimer’s disease
by: Verdile, Giuseppe, et al.
Published: (2015)

Utility of an Alzheimer's Disease Risk-Weighted Polygenic Risk Score for Predicting Rates of Cognitive Decline in Preclinical Alzheimer's Disease: A Prospective Longitudinal Study.
by: Porter, T., et al.
Published: (2018)

Cannot write session to /tmp/vufind_sessions/sess_gmmvit4rlujqktmgt540r6g27k