Evidence for and against a pathogenic role for reduced γ-secretase activity in familial Alzheimer’s disease

Evidence for and against a pathogenic role for reduced γ-secretase activity in familial Alzheimer’s disease

The majority of mutations causing familial Alzheimer’s disease (fAD) have been found in the gene PRESENILIN1 (PSEN1 ) with additional mutations in the related gene PRESENILIN2 (PSEN2 ). The best characterized function of PRESENILIN (PSEN) proteins is in γ-secretase enzyme activity. One substrate of...

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Bibliographic Details
Main Authors: Verdile, Giuseppe, Jayne, T., Newman, M., Sutherland, G., Munch, G., Musgrave, I., Moussavi Nik, H., Lardelli, M.
Format: Journal Article
Published: IOS Press 2016
Online Access:http://hdl.handle.net/20.500.11937/32300

Internet

http://hdl.handle.net/20.500.11937/32300

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