How Do Fatty Acids Cause Allosteric Binding of Drugs to Human Serum Albumin?

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How Do Fatty Acids Cause Allosteric Binding of Drugs to Human Serum Albumin?

Purpose. This study was undertaken to investigate how fatty acids cause the allosteric binding of drugs to human serum albumin (HSA). The influence of fatty acids on the binding of ketoprofen (KP), an NSAID, to HSA was examined by using a photoaffinity labeling technique. Methods. Ultrafiltration wa...

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Bibliographic Details
Main Authors:	Chuang, Victor, Otagiri, M.
Format:	Journal Article
Published:	AAPS 2002
Subjects:	human serum albumin - ketoprofen - fatty acid - photoaffinity labeling - allosteric binding - chain length
Online Access:	http://hdl.handle.net/20.500.11937/32173

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