How Do Fatty Acids Cause Allosteric Binding of Drugs to Human Serum Albumin?

QR Code

How Do Fatty Acids Cause Allosteric Binding of Drugs to Human Serum Albumin?

Purpose. This study was undertaken to investigate how fatty acids cause the allosteric binding of drugs to human serum albumin (HSA). The influence of fatty acids on the binding of ketoprofen (KP), an NSAID, to HSA was examined by using a photoaffinity labeling technique. Methods. Ultrafiltration wa...

Full description

Bibliographic Details
Main Authors:	Chuang, Victor, Otagiri, M.
Format:	Journal Article
Published:	AAPS 2002
Subjects:	human serum albumin - ketoprofen - fatty acid - photoaffinity labeling - allosteric binding - chain length
Online Access:	http://hdl.handle.net/20.500.11937/32173

Similar Items

Histidine146 of Human Serum Albumin Plays a Prominent Role at the Interface of Subdomains IA and IIA in Allosteric Ligand Binding
by: Kaneko, K., et al.
Published: (2011)

Stereoselective Binding of Human Serum Albumin
by: Chuang, Victor, et al.
Published: (2006)

Flunitrazepam, a 7-nitro-1,4-benzodiazepine that is unable to bind to the indole-benzodiazepine site of human serum albumin
by: Chuang, Victor, et al.
Published: (2001)

Photoaffinity labeling of plasma proteins
by: Chuang, Victor, et al.
Published: (2013)

Helix 6 of subdomain III A of human serum albumin is the region primarily photolabeled by ketoprofen, an arylpropionic acid NSAID containing a benzophenone moiety
by: Chuang, Victor, et al.
Published: (1999)

Albumin-drug interaction and its clinical implication
by: Yamasaki, K., et al.
Published: (2013)

Redox properties of serum albumin
by: Anraku, M., et al.
Published: (2013)

Development of halal plant-based hydrocolloids encapsulation for targeted delivery of bovine serum albumin
by: Mohamed, Hajaratul Najwa
Published: (2015)

Practical Aspects of the Ligand-Binding and Enzymatic Properties of Human Serum Albumin
by: Kragh-Hansen, U., et al.
Published: (2002)

Characterisation of bovine serum albumin-based biomaterials synthesised by subcritical water technology
by: Esfahan, Zahra Maghareh
Published: (2019)

Preparation of a Monolith with Covalently Bound Bovine Serum Albumin for Capillary Electrochromatography
by: Yao, C., et al.
Published: (2012)

Part A: Outlining the current state of AAVs & evaluating albumins potential role in AAV stability / Part B: Comparing separation resolution of multiple SEC columns & evaluating AAV-albumin interactions
by: Hughes, Oliver
Published: (2024)

Biased allosteric modulators of metabotropic glutamate receptor 5
by: Sengmany, Kathy
Published: (2018)

Understanding the role of serum albumin on the regulation of drug uptake transporters in the liver
by: Kanwar, Nisha
Published: (2025)

Purification and characterization of polyclonal anti-hepatitis B core antigen immunoglobulin G from rabbit serum
by: Sayed Hitam, Sharifah Mariam
Published: (2016)

Drug-loaded hydrogel microneedles for sustainable transdermal delivery of macromolecular proteins
by: Chandran, Rubhan, et al.
Published: (2025)

Alkyl-modified oligonucleotides as intercalating vehicles for doxorubicin uptake via albumin binding
by: Purdie, Laura, et al.
Published: (2018)

Universal sensors for identifying use-dependent intracellular allosteric modulators of G protein coupled receptors
by: Farmer, James
Published: (2024)

Recombinant human serum albumin
by: Chuang, Victor, et al.
Published: (2007)

Long chain fatty acids alter the interactive binding of ligands to the two principal drug binding sites of human serum albumin
by: Yamasaki, K., et al.
Published: (2017)

Design, Synthesis, and Development of Novel Fluorescently Labelled Allosteric Probes for the Human Beta2-Adrenoceptor
by: Tuzer, Cemre
Published: (2023)

Pharmaceutically Important Pre- and Posttranslational Modifications on Human Serum Albumin
by: Otagiri, M., et al.
Published: (2009)

Allosteric interactions at adenosine A1 and A3 receptors: new insights into the role of small molecules and receptor dimerization
by: Hill, Stephen J., et al.
Published: (2014)

Part A: The stability of Adenoviral and mRNA based COVID-19 vaccines and the potential of HSA/ Part B: Characterisation of IgG A33 hFab’ and human serum albumin using hydrodynamic methods
by: Abu Hammad, Khalil
Published: (2021)

Neuropsychological Performance is Positively Associated with Plasma Albumin in Healthy Adults
by: Lam, Virginie, et al.
Published: (2014)

Bacterial and short-chain fatty acid profiling of faecal samples
by: Faujan, Nur Huda
Published: (2011)

Relationship between exposure of airborne pesticides with concentration of pesticide residue in blood serum among farmers in Tanjung Karang, Malaysia
by: Rudzi, Siti Khairunnisaq
Published: (2021)

Negative cooperativity across 1-adrenoceptor homodimers provides insights into the nature of the secondary low-affinity CGP 12177 1-adrenoceptor binding conformation
by: Gherbi, Karolina, et al.
Published: (2015)

Examining the mechanism of action of small-molecule negative allosteric modulators of the human chemokine receptor CXCR2
by: Nesheva, Desislava
Published: (2022)

A monoclonal antibody raised against a thermo-stabilised β1-adrenoceptor interacts with extracellular loop 2 and acts as a negative allosteric modulator of a sub-set of 1- adrenoceptors expressed in stable cell lines
by: Soave, Mark, et al.
Published: (2018)

Pharmacokinetically modified human serum albumin based therapeutic design and development
by: Taguchi, K., et al.
Published: (2015)

Producing Cyclopropane Fatty Acid in Plant Leafy Biomass via Expression of Bacterial and Plant Cyclopropane Fatty Acid Synthases
by: Okada, Shoko, et al.
Published: (2020)

Arginine 485 of human serum albumin interacts with the benzophenone moiety of ketoprofen in the binding pocket of subdomain III A and III B
by: Kaneko, K., et al.
Published: (2012)

Stripping voltammetric detection of insulin at liquid–liquid microinterfaces in the presence of bovine albumin
by: O'Sullivan, S., et al.
Published: (2013)

Synthesis and characterization of ion-imprinted polymer for determination of ionized calcium in human blood serum
by: Al-Maibd, Rafah Jasim Mohammed
Published: (2021)

Pharmaceutical Aspects of the Recombinant Human Serum Albumin Dimer: Structural Characteristics, Biological Properties, and Medical Applications
by: Taguchi, K., et al.
Published: (2012)

Factors influencing the removal of immune complex deposits from the renal glomerulus
by: Furness, Peter Norman
Published: (1988)

Differential Effects of Methoxy Group on the Interaction of Curcuminoids with Two Major Ligand Binding Sites of Human Serum Albumin
by: Sato, H., et al.
Published: (2014)

Measuring and modelling the response of Klebsiella pneumoniae KPC prey to Bdellovibrio bacteriovorus predation, in human serum and defined buffer
by: Baker, Michelle, et al.
Published: (2017)

Subdomain IIIA of Dog Albumin Contains a Binding Site Similar to Site II of Human Albumin
by: Kaneko, K., et al.
Published: (2008)