Preliminary studies on the development of IgA-loaded chitosan-dextran sulphate nanoparticles as a potential nasal delivery system for protein antigens.

Preliminary studies on the development of IgA-loaded chitosan-dextran sulphate nanoparticles as a potential nasal delivery system for protein antigens.

This study describes the development of a biodegradable nanoparticulate system for the intranasal delivery of multiple proteins. Chitosan (CS)–dextran sulphate (DS) nanoparticles were developed and optimised for the incorporation of pertussis toxin (PTX) and a potential targeting ligand (immunoglobu...

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Bibliographic Details
Main Authors: Sharma, Sameer, Benson, Heather, Mukkur, Trilochan, Rigby, P., Chen, Y.
Format: Journal Article
Published: Informa Healthcare 2013
Subjects:
complex coacervation
pertussis toxoid
mucosal delivery
M cells
nasopharynx-associated lymphoid tissue
nanoparticles
vaccine
Online Access:http://hdl.handle.net/20.500.11937/32009

Internet

http://hdl.handle.net/20.500.11937/32009

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