Collagen matrix deposition is dramatically enhanced in vitro when crowded with charged macromolecules: The biological relevance of the excluded volume effect

Collagen matrix deposition is dramatically enhanced in vitro when crowded with charged macromolecules: The biological relevance of the excluded volume effect

The excluded volume effect (EVE) rules all life processes. It is created by macromolecules that occupy a given volume thereby confining other molecules to the remaining space with large consequences on reaction kinetics and molecular assembly. Implementing EVE in fibroblast culture accelerated conve...

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Bibliographic Details
Main Authors: Lareu, Ricky R., Subramhanya, H., Peng, Y., Benny, P., Chen, C., Wang, Z., Rajagopalan, R., Raghunath, M.
Format: Journal Article
Published: Elsevier Science BV 2007
Subjects:
Macromolecular crowding
Extracellular matrix
Procollagen C-proteinase
Excluded volume effect
Collagen deposition
Online Access:http://hdl.handle.net/20.500.11937/31588

Internet

http://hdl.handle.net/20.500.11937/31588

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