Arginine 485 of human serum albumin interacts with the benzophenone moiety of ketoprofen in the binding pocket of subdomain III A and III B

Arginine 485 of human serum albumin interacts with the benzophenone moiety of ketoprofen in the binding pocket of subdomain III A and III B

Arylpropionic acid nonsteroidal anti-inflammatory drusg (NSAIDs) primarily bind to subdomain III A (site II) of human serum albumin (HSA). Ketoprofen (KP), an arylpropionic acid that contains a photoreactive benzophenone moiety, was used to photolabel the binding region of site II. LC/Q-TOF mass spe...

Full description

Bibliographic Details
Main Authors: Kaneko, K., Chuang, Victor, Ito, T., Suenaga, A., Watanabe, H., Maruyama, T., Otagiri, M.
Format: Journal Article
Published: Govi Verlag Pharmazeutischer Verlag GmbH 2012
Online Access:http://hdl.handle.net/20.500.11937/31373

Internet

http://hdl.handle.net/20.500.11937/31373

Similar Items