Demonstration that CobG, the monooxygenase associated with the ring contraction process of the aerobic cobalamin (vitamin B12) biosynthetic pathway, contains an Fe-S center and a mononuclear non-heme iron center

Demonstration that CobG, the monooxygenase associated with the ring contraction process of the aerobic cobalamin (vitamin B12) biosynthetic pathway, contains an Fe-S center and a mononuclear non-heme iron center

The ring contraction process that occurs during cobalamin (vitamin B12) biosynthesis is mediated via the action of two enzymes, CobG and CobJ. The first of these generates a tertiary alcohol at the C-20 position of precorrin-3A by functioning as a monooxygenase, a reaction that also forms a gamma la...

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Bibliographic Details
Main Authors: Schroeder, S., Lawrence, A., Biedendieck, R., Rose, R., Deery, E., Graham, Ross, McLean, K., Munro, A., Rigby, S., Warren, M.
Format: Journal Article
Published: The American Society for Biochemistry and Molecular Biology Inc 2009
Online Access:http://hdl.handle.net/20.500.11937/31299

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