The adaptor protein 14-3-3 binds to the calcium-sensing receptor and attenuates receptor-mediated Rho kinase signalling

QR Code

The adaptor protein 14-3-3 binds to the calcium-sensing receptor and attenuates receptor-mediated Rho kinase signalling

A yeast two-hybrid screen performed to identify binding partners of the CaR (calcium-sensing receptor) intracellular tail identified the adaptor protein 14-3-3? as a novel binding partner that bound to the proximal membrane region important for CaR expression and signalling. The 14-3-3? protein dire...

Full description

Bibliographic Details
Main Authors:	Arulpragasam, Ajanthy, Magno, A., Ingley, E., Brown, S., Conigrave, A., Ratajczak, T., Ward, B.
Format:	Journal Article
Published:	2012
Online Access:	http://hdl.handle.net/20.500.11937/31034

Similar Items

The endoplasmic reticulum-associated protein, OS-9, behaves as a lectin in targeting the immature calcium-sensing receptor
by: Ward, B., et al.
Published: (2017)

The helix 1-3 loop in the glucocorticoid receptor LBD is a regulatory element for FKBP cochaperones
by: Cluning, C., et al.
Published: (2013)

Pathophysiological role of RhoA/Rho-kinase under oxygen-glucose deprivation/reperfusion and hyperglycaemia
by: Srivastava, Kirtiman
Published: (2013)

Roles of Rho-associated kinase in lung cancer review
by: Zakaria, Muhammad Asyaari, et al.
Published: (2020)

Modeling of Insulin Receptor Modeling of Insulin Receptor Binding & Recycling Binding & Recycling Subsystem
by: Ismail, Nor Faekah
Published: (2007)

Design and synthesis of benzimidazole-based Rho kinase inhibitors for the treatment of glaucoma
by: Abbhi, V., et al.
Published: (2017)

Real-time analysis of the binding of fluorescent VEGF₁₆₅a to VEGFR2 in living cells: Effect of receptor tyrosine kinase inhibitors and fate of internalized agonist-receptor complexes
by: Kilpatrick, Laura E., et al.
Published: (2017)

Role of RhoGDIα on migration and invasion of estrogen receptor positive MCF7 and estrogen receptor negative MDA-MB-231 breast cancer cells
by: Hooshmand, Somayeh
Published: (2014)

Inhibition of transforming growth factor-β via the activin receptor-like kinase-5 inhibitor attenuates pulmonary fibrosis
by: Koh, Rhun Yian, et al.
Published: (2015)

Selective binding and release of aspirin by an encapsulating receptor
by: Nguyen, Thanh Vinh, et al.
Published: (2010)

Development of medium throughput muscarinic receptor binding assay
by: Yap, Kim Fah, et al.
Published: (2004)

Blocking the tropomyosin receptor kinase A (TrkA) receptor inhibits pain behaviour in two rat models of osteoarthritis
by: Nwosu, Lilian Ngozi, et al.
Published: (2015)

Characterisation of Recombinant Aryl Hydrocarbon Receptor Ligand Binding Domain
by: Jiang, Tao
Published: (2004)

Cell adhesion: stochastic receptor-ligand binding under force
by: Bagdasar, Ovidiu
Published: (2011)

Effect of Mannose Receptor (MR)-binding polymers on human macrophages
by: de Medeiros Costa, Diego
Published: (2019)

The helminth product ES-62 protects against septic shock via Toll-like receptor 4-dependent autophagosomal degradation of the adaptor MyD88
by: Puneet, P., et al.
Published: (2011)

Expression of the Caenorhabditis elegans aryl hydrocarbon receptor ligand binding domain
by: Helaly, Ahmed
Published: (2011)

Recombinant expression of Aryl Hydrocarbon Receptor for quantitative ligand-binding analysis
by: Fan, MingQi, et al.
Published: (2009)

QSAR study of platelet-activating factor (PAF) receptor binding antagonist
by: Abdullah, Nor Hayati, et al.
Published: (2013)

Alzheimer's beta-amyloid peptides compete for insulin binding to the insulin receptor
by: Xie, Ling, et al.
Published: (2002)

Characterization of candidate receptor proteins that bind dengue viruses using proteomics
by: Jong, Wan Wui.
Published: (2006)

Prediction of co-receptor binding of HIV-1 virus of Kelantan based on sequence analysis of V3 loop structure
by: Min, Ong Si
Published: (2013)

QSAR study of flavonoids as platelet-activating factor (PAF) receptor binding antagonists
by: Abdullah, Nor Hayati, et al.
Published: (2014)

Benzalhydantoin derivative-based inhibitors of eight receptor tyrosine kinases: synthesis, in-vitro, and in-silico study
by: Muhammad Naufal,, et al.
Published: (2025)

Determination of gene expression of tyrosine kinase receptors (HER family) in FFPE tissue of colorectal adenocarcinoma
by: Othman @ Jaffar, Rosfayati, et al.
Published: (2015)

NanoBRET to probe ligand-receptor and receptor-receptor interactions in living cells
by: Carvalheira Alcobia, Diana
Published: (2019)

A functional 14-3-3{zeta}-independent association of PI3-kinase with glycoprotein Ib{alpha}, the major ligand-binding subunit of the platelet glycoprotein Ib-IX-V complex
by: Mu, F., et al.
Published: (2008)

Further genetic evidence suggesting a role for the RhoGTPase-RhoGEF pathway in osteoporosis.
by: Mullin, B., et al.
Published: (2009)

Cannabinoid CB1 receptor binding and acetylcholinesterase inhibitory activity of Sceletium tortuosum L.
by: Lubbe, A., et al.
Published: (2010)

Adenosine A1 receptor binding activity of methoxy flavonoids from orthosiphon stamineus
by: Yuliana, Nancy Dewi, et al.
Published: (2009)

Cannabinoid CB1 receptor binding and acetylcholinesterase inhibitory activity of Sceletium tortuosum L.
by: Lubbe, Andrea, et al.
Published: (2010)

Inhibitory effects of compounds from Zingiberaceae species on platelet activating factor receptor binding
by: Jantan, Ibrahim, et al.
Published: (2004)

An investigation into the effects of the epidermal growth factor receptor tyrosine kinase inhibitor "Gefitinib" on human breast cancer
by: Gutteridge, Eleanor
Published: (2010)

Effects of 4 multitargeted receptor tyrosine kinase inhibitors on regional hemodynamics in conscious, freely moving rats
by: Carter, Joanne J., et al.
Published: (2016)

Linifanib – a multi-targeted receptor tyrosine kinase inhibitor and a low molecular weight gelator
by: Marlow, Maria, et al.
Published: (2015)

The contribution of protein kinase C in P2Y receptor-evoked vasoconstriction of rat pulmonary artery
by: Tengah, A, et al.
Published: (2011)

Distinct role of kappa opioid receptor in attenuating relapse to morphine/methamphetamine (polydrug) dependence
by: Ridzwan, Irna Elina, et al.
Published: (2017)

Analysis of Leptin receptor, Glucocorticoid receptor,B-3 Aderenergic receptor and Tumour Necrosis Factor-a Gene Polymorphism in Type 2 Diabetes Mellitus in Kelantan Malays.
by: Isa, Nizam, et al.
Published: (2003)

Activation of phosphatidylinositol 3-kinase ß by the platelet collagen receptors integrin a2ß1 and GPVI: The role of Pyk2 and c-Cbl
by: Manganaro, D., et al.
Published: (2015)

Receptors, sparks and waves in a fire-diffuse-fire framework for calcium release
by: Coombes, Stephen, et al.
Published: (2004)

Cannot write session to /tmp/vufind_sessions/sess_ttigsl614j024ofa1vco1vcuct