Meningeal inflammation increases cerebrospinal fluid artemether concentrations in Papua New Guinean children treated with intramuscular artemether

Although the artemisinin-associated neurotoxicity identified in vitro and in animal studies has not been confirmed clinically, only one adult study has measured cerebrospinal fluid (CSF) concentrations after administration of conventional doses. Potential artemisinin neurotoxicity could be serious i...

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Bibliographic Details
Main Authors: Manning, L., Laman, M., Page-Sharp, Madhu, Salman, S., Hwaiwhanje, I., Morep, N., Siba, P., Mueller, I., Karunajeewa, H., Davis, T.
Format: Journal Article
Published: American Society for Microbiology 2011
Online Access:http://hdl.handle.net/20.500.11937/31019