Computational analyses of the catalytic and heparin binding sites and their interactions with glycosaminoglycans in glycoside hydrolase family 79 endo-β-D-glucuronidase (heparanase)
Mammalian heparanase is an endo-β-glucuronidase associated with cell invasion in cancer metastasis, angiogenesis and inflammation. Heparanase cleaves heparan sulfate proteoglycans in the extracellular matrix and basement membrane, releasing heparin/heparan sulfate oligosaccharides of appreciable siz...
| Main Authors: | , , , |
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| Format: | Journal Article |
| Published: |
Oxford University Place
2012
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| Online Access: | http://hdl.handle.net/20.500.11937/30588 |