Changes in Brain Transcripts Related to Alzheimer’s Disease in a Model of HFE Hemochromatosis are not Consistent with Increased Alzheimer’s Disease Risk

Changes in Brain Transcripts Related to Alzheimer’s Disease in a Model of HFE Hemochromatosis are not Consistent with Increased Alzheimer’s Disease Risk

Iron abnormalities are observed in the brains of Alzheimer's disease (AD) patients, but it is unclear whether common disorders of systemic iron overload such as hemochromatosis alter risks of AD. We used microarrays and real-time reverse transcription-PCR to investigate changes in the brain tra...

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Bibliographic Details
Main Authors: Johnstone, D., Graham, Ross, Trinder, D., Riveros, C., Olynyk, John, Scott, R., Moscato, P., Milward, E.
Format: Journal Article
Published: IOS Press 2012
Subjects:
notch signaling
secretase
hemochromatosis
HFE
Amyloid-protein precursor
iron
Online Access:http://hdl.handle.net/20.500.11937/30366

Internet

http://hdl.handle.net/20.500.11937/30366

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