Identification of a Glycogen Synthase Kinase-3β Inhibitor that Attenuates Hyperactivity in CLOCK Mutant Mice

Identification of a Glycogen Synthase Kinase-3β Inhibitor that Attenuates Hyperactivity in CLOCK Mutant Mice

Bipolar disorder is characterized by a cycle of mania and depression, which affects approximately 5 million people in the United States. Current treatment regimes include the so-called “mood-stabilizing drugs”, such as lithium and valproate that are relatively dated drugs with various known side eff...

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Bibliographic Details
Main Authors: Kozikowski, A., Gunosewoyo, Hendra, Guo, S., Gaisina, I., Walter, R., Ketcherside, A., McClung, C., Mesecar, A., Caldarone, B.
Format: Journal Article
Published: Wiley-VCH Verlag GmbH & Co. KGaA 2011
Subjects:
GSK-3 inhibitors
circadian rhythms
bipolar disorder
antimanic agents
CLOCK mutant mice
Online Access:http://hdl.handle.net/20.500.11937/30218

Internet

http://hdl.handle.net/20.500.11937/30218

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