Differential effects of chemotherapeutic drugs versus the MDM-2 antagonist Nutlin-3 on cell cycle progression and induction of apoptosis in SKW6.4 lymphoblastoid B-cells

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Differential effects of chemotherapeutic drugs versus the MDM-2 antagonist Nutlin-3 on cell cycle progression and induction of apoptosis in SKW6.4 lymphoblastoid B-cells

We have compared the cytotoxic/cytostatic responses of the SKW6.4 lymphoblastoid B-cells to the alkylating agent chlorambucil, the purine analog fludarabine, the non-genotoxic activator of the p53 pathway, Nutlin-3, used alone or in association with the death-inducing ligand recombinant TRAIL. Expos...

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Bibliographic Details
Main Authors:	Barbarotto, E., Corallini, F., Rimondi, E., Fadda, R., Mischiati, C., Grill, V., Vaccarezza, Mauro, Celeghini, C.
Format:	Journal Article
Published:	2008
Online Access:	http://hdl.handle.net/20.500.11937/3008

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