Role of Focal Adhesion Tyrosine Kinases in GPVI-Dependent Platelet Activation and Reactive Oxygen Species Formation

QR Code

Role of Focal Adhesion Tyrosine Kinases in GPVI-Dependent Platelet Activation and Reactive Oxygen Species Formation

BackgroundWe have previously shown the presence of a TRAF4/p47phox/Hic5/Pyk2 complex associated with the platelet collagen receptor, GPVI, consistent with a potential role of this complex in GPVI-dependent ROS formation. In other cell systems, NOX-dependent ROS formation is facilitated by Pyk2, whic...

Full description

Bibliographic Details
Main Authors:	Carrim, N., Walsh, T., Consonni, A., Torti, M., Berndt, Michael, Metharom, Pat
Format:	Journal Article
Published:	Public Library of Science 2014
Online Access:	http://hdl.handle.net/20.500.11937/29835

Similar Items

The role of NADPH oxidase (NOX) 1 and 2 in GPVI-dependent platelet activation and thrombus formation
by: Walsh, T., et al.
Published: (2013)

PYK2 is prerequisite for GPVI-induced platelet ROS production, but not aggregation
by: Walsh, T., et al.
Published: (2011)

The role of Nox1 and Nox2 in GPVI-dependent platelet activation and thrombus formation
by: Walsh, T., et al.
Published: (2014)

The role of the focal adhesion kinase Pyk2 in platelet activation
by: Cipolla, L., et al.
Published: (2011)

The role of the focal adhesion kinase PYK2 in platelet activation
by: Canobbio, I., et al.
Published: (2011)

The focal adhesion kinase Pyk2 links Ca2+ signalling to Src family kinase activation and protein tyrosine phosphorylation in thrombin-stimulated platelets
by: Canobbio, I., et al.
Published: (2015)

Liver-mediated shedding of platelet GPVI
by: Berndt, Michael, et al.
Published: (2016)

Impaired thrombin-induced platelet activation and thrombus formation in mice lacking the Ca2+-dependent tyrosine kinase Pyk2
by: Canobbio, I., et al.
Published: (2013)

The proline-rich tyrosine kinase Pyk2 regulates platelet integrin aIIbß3 outside-in signaling
by: Cipolla, L., et al.
Published: (2013)

Thrombin-induced reactive oxygen species generation in platelets: A novel role for protease-activated receptor 4 and GPIba.
by: Carrim, N., et al.
Published: (2015)

Activation of phosphatidylinositol 3-kinase ß by the platelet collagen receptors integrin a2ß1 and GPVI: The role of Pyk2 and c-Cbl
by: Manganaro, D., et al.
Published: (2015)

The functional role of platelets in the regulation of angiogenesis
by: Walsh, T., et al.
Published: (2015)

The tyrosine kinase Pyk2 mediates the cross-talk between platelet integrins alpha 2 beta 1 and alpha IIb beta 3
by: Guidetti, G., et al.
Published: (2011)

The tyrosine kinase PYK2 mediates the cross-talk between platelet integrins alpha 2 beta 1 and alpha iib beta 3
by: Guidetti, G., et al.
Published: (2011)

Oligomeric and fibrillar amyloid beta 42 induce platelet aggregation partially through GPVI
by: Elaskalani, O., et al.
Published: (2017)

Presence of platelet-associated anti-glycoprotein (GP)VI autoantibodies and restoration of GPVI expression in patients with GPVI deficiency
by: Akiyama, M., et al.
Published: (2009)

GPIba-selective activation of platelets induces platelet signaling events comparable to GPVI activation events
by: Gardiner, E., et al.
Published: (2010)

Src family tyrosine kinase Lyn mediates VWF GPIb-IX induced platelet activation via the cGMP signaling pathway
by: Yin, H., et al.
Published: (2008)

Targeting platelets for the treatment of cancer
by: Elaskalani, Omar, et al.
Published: (2017)

A brief history of blood platelets: A personal view
by: Berndt, Michael, et al.
Published: (2017)

Platelet adhesion: A game of catch and release
by: Andrews, R., et al.
Published: (2008)

Editorial: Platelet hem-Immunoreceptor Tyrosine-Based Activation Motif Receptors: At Lease One Required
by: Berndt, Michael, et al.
Published: (2013)

ITAM receptor-mediated generation of reactive oxygen species in human platelets occurs via Syk-dependent and Syk-independent pathways
by: Arthur, J., et al.
Published: (2012)

Constitutive Dimerization of Glycoprotein VI (GPVI) in Resting Platelets Is Essential for Binding to Collagen and Activation in Flowing Blood
by: Jung, S., et al.
Published: (2012)

CHARACTERIZING THE BINDING SITE OF GPVI INHIBITORS FOR THE DEVELOPMENT OF NOVEL ANTI-PLATELET AGENTS
by: Damaskinaki, Foteini-Nafsika
Published: (2023)

Role and regulation of phosphatidylinositol 3-kinase ß in platelet integrin α2ß1 signaling
by: Consonni, A., et al.
Published: (2012)

Anti-glycoprotein VI monoclonal antibodies directly aggregate platelets independently of Fc?RIIa and induce GPVI ectodomain shedding
by: Al-Tamimi, M., et al.
Published: (2009)

Bile salt chenodeoxycholate suppresses normal platelet functions through cyclic amp activation pathway
by: Metharom, Pat, et al.
Published: (2015)

High shear-dependent loss of membrane integrity and defective platelet adhesion following disruption of the GPIba-filamin interaction
by: Cranmer, S., et al.
Published: (2011)

Platelets — Allies of Tumour Cells
by: Metharom, Pat, et al.
Published: (2015)

Self-assembling tyrosine kinase inhibitors for localised targeted delivery
by: Al-Ameedee, Mohammed
Published: (2017)

An apoferritin-based drug delivery system for the tyrosine kinase inhibitor gefitinib
by: Kuruppu, Anchala I., et al.
Published: (2015)

The role of platelet-derived ADP and ATP in promoting pancreatic cancer cell survival and gemcitabine resistance
by: Elaskalani, Omar, et al.
Published: (2017)

EGFR-directed tyrosine kinase inhibitors for non-small cell lung cancer
by: Fatin Nur Elyana Mohd Sidek,, et al.
Published: (2025)

Adaptive therapy to circumvent drug resistance to tyrosine kinase inhibitors in cancer: is it clinically relevant?
by: Hamdi, Amir Imran Faisal, et al.
Published: (2022)

The role of reactive oxygen species in pressure-dependent myogenic tone
by: Satirah Zainalabidin,, et al.
Published: (2012)

Novel strategies for assessing platelet reactivity
by: Algahtani, Mohammad, et al.
Published: (2017)

Benzalhydantoin derivative-based inhibitors of eight receptor tyrosine kinases: synthesis, in-vitro, and in-silico study
by: Muhammad Naufal,, et al.
Published: (2025)

Case series of small cell lung cancer transformation post tyrosine kinase inhibitor failure
by: Chai, C.S., et al.
Published: (2017)

Determination of gene expression of tyrosine kinase receptors (HER family) in FFPE tissue of colorectal adenocarcinoma
by: Othman @ Jaffar, Rosfayati, et al.
Published: (2015)