Cubyl amides: Novel P2X7 receptor antagonists

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Cubyl amides: Novel P2X7 receptor antagonists

Polycyclic amides 2 and 5–9 were successfully synthesised and their lipophilicity profiles were evaluated using reverse-phase HPLC. All synthesised compounds possessed P2X7R antagonistic properties when tested on rat spinal cord microglia cells. Extensive screening for binding to other neuroreceptor...

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Bibliographic Details
Main Authors:	Gunosewoyo, Hendra, Guo, J., Bennett, M., Coster, M., Kassiou, M.
Format:	Journal Article
Published:	Pergamon 2008
Subjects:	Polycyclic benzamides P2X7 antagonists Microglia Rational drug design
Online Access:	http://hdl.handle.net/20.500.11937/29736

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