Cubyl amides: Novel P2X7 receptor antagonists
Polycyclic amides 2 and 5–9 were successfully synthesised and their lipophilicity profiles were evaluated using reverse-phase HPLC. All synthesised compounds possessed P2X7R antagonistic properties when tested on rat spinal cord microglia cells. Extensive screening for binding to other neuroreceptor...
| Main Authors: | , , , , |
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| Format: | Journal Article |
| Published: |
Pergamon
2008
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| Subjects: | |
| Online Access: | http://hdl.handle.net/20.500.11937/29736 |