Cubyl amides: Novel P2X7 receptor antagonists
Polycyclic amides 2 and 5–9 were successfully synthesised and their lipophilicity profiles were evaluated using reverse-phase HPLC. All synthesised compounds possessed P2X7R antagonistic properties when tested on rat spinal cord microglia cells. Extensive screening for binding to other neuroreceptor...
| Main Authors: | , , , , |
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| Format: | Journal Article |
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Pergamon
2008
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| Online Access: | http://hdl.handle.net/20.500.11937/29736 |
| _version_ | 1848752884955480064 |
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| author | Gunosewoyo, Hendra Guo, J. Bennett, M. Coster, M. Kassiou, M. |
| author_facet | Gunosewoyo, Hendra Guo, J. Bennett, M. Coster, M. Kassiou, M. |
| author_sort | Gunosewoyo, Hendra |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Polycyclic amides 2 and 5–9 were successfully synthesised and their lipophilicity profiles were evaluated using reverse-phase HPLC. All synthesised compounds possessed P2X7R antagonistic properties when tested on rat spinal cord microglia cells. Extensive screening for binding to other neuroreceptor subtypes demonstrated their P2X7 selectivity. |
| first_indexed | 2025-11-14T08:15:43Z |
| format | Journal Article |
| id | curtin-20.500.11937-29736 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T08:15:43Z |
| publishDate | 2008 |
| publisher | Pergamon |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-297362017-09-13T15:27:37Z Cubyl amides: Novel P2X7 receptor antagonists Gunosewoyo, Hendra Guo, J. Bennett, M. Coster, M. Kassiou, M. Polycyclic benzamides P2X7 antagonists Microglia Rational drug design Polycyclic amides 2 and 5–9 were successfully synthesised and their lipophilicity profiles were evaluated using reverse-phase HPLC. All synthesised compounds possessed P2X7R antagonistic properties when tested on rat spinal cord microglia cells. Extensive screening for binding to other neuroreceptor subtypes demonstrated their P2X7 selectivity. 2008 Journal Article http://hdl.handle.net/20.500.11937/29736 10.1016/j.bmcl.2008.05.062 Pergamon restricted |
| spellingShingle | Polycyclic benzamides P2X7 antagonists Microglia Rational drug design Gunosewoyo, Hendra Guo, J. Bennett, M. Coster, M. Kassiou, M. Cubyl amides: Novel P2X7 receptor antagonists |
| title | Cubyl amides: Novel P2X7 receptor antagonists |
| title_full | Cubyl amides: Novel P2X7 receptor antagonists |
| title_fullStr | Cubyl amides: Novel P2X7 receptor antagonists |
| title_full_unstemmed | Cubyl amides: Novel P2X7 receptor antagonists |
| title_short | Cubyl amides: Novel P2X7 receptor antagonists |
| title_sort | cubyl amides: novel p2x7 receptor antagonists |
| topic | Polycyclic benzamides P2X7 antagonists Microglia Rational drug design |
| url | http://hdl.handle.net/20.500.11937/29736 |