Chemosensitization of solid tumors by inhibition of Bcl-xL expression using DNAzyme.

Chemosensitization of solid tumors by inhibition of Bcl-xL expression using DNAzyme.

DNAzymes are a novel class of gene suppressors that selectively bind to an RNA substrate by Watson-Crick base pairing and cleave phosphodiester bonds. To explore the potential for therapeutic use of catalytic DNA molecules, active DNAzymes targeting the bcl-xL gene were generated through a multiplex...

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Bibliographic Details
Main Authors: Yu, X., Yang, L., Cairns, M., Dass, Crispin, Saravolac, E., Li, X., Sun, L.
Format: Journal Article
Published: Impact Journals LLC 2014
Subjects:
apoptosis
bcl-xL
chemosensitization
DNAzyme
Online Access:http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path%5B%5D=1996
http://hdl.handle.net/20.500.11937/29674

Internet

http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path%5B%5D=1996
http://hdl.handle.net/20.500.11937/29674

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