Metabolomic analyses reveal profound differences in glycolytic and tricarboxylic acid cycle metabolism in glucose-responsive and -unresponsive clonal ß-cell lines

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Metabolomic analyses reveal profound differences in glycolytic and tricarboxylic acid cycle metabolism in glucose-responsive and -unresponsive clonal ß-cell lines

Insulin secretion from pancreatic β-cells is controlled by complex metabolic and energetic changes provoked by exposure to metabolic fuels. Perturbations in these processes lead to impaired insulin secretion, the ultimate cause of T2D (Type 2 diabetes). To increase our understanding of stimulus–secr...

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Bibliographic Details
Main Authors:	Spegel, P., Malmgren, S., Newsholme, Philip, Koeck, T., Mulder, H., Sharoyko, V.
Format:	Journal Article
Published:	Portland Press Ltd. 2011
Subjects:	Type 2 diabetes (T2D) mitochondria pancreatic islet insulin hypoxia-inducible factor (HIF)
Online Access:	http://hdl.handle.net/20.500.11937/29460

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