A comparative structural bioinformatics analysis of the insulin receptor family ectodomain based on phylogenetic information

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A comparative structural bioinformatics analysis of the insulin receptor family ectodomain based on phylogenetic information

The insulin receptor (IR), the insulin-like growth factor 1 receptor (IGF1R) and the insulin receptor-related receptor (IRR) are covalently-linked homodimers made up of several structural domains. The molecular mechanism of ligand binding to the ectodomain of these receptors and the resulting activa...

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Bibliographic Details
Main Authors:	Renteria, Miguel, Gandhi, Neha, Vinuesa, P., Helmerhorst, Erik, Mancera, Ricardo
Format:	Journal Article
Published:	Public Library of Science (PLoS) 2008
Online Access:	http://hdl.handle.net/20.500.11937/29028

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