A comparative structural bioinformatics analysis of the insulin receptor family ectodomain based on phylogenetic information
The insulin receptor (IR), the insulin-like growth factor 1 receptor (IGF1R) and the insulin receptor-related receptor (IRR) are covalently-linked homodimers made up of several structural domains. The molecular mechanism of ligand binding to the ectodomain of these receptors and the resulting activa...
| Main Authors: | , , , , |
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| Format: | Journal Article |
| Published: |
Public Library of Science (PLoS)
2008
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| Online Access: | http://hdl.handle.net/20.500.11937/29028 |