Hypomethylation of the CTGF gene locus is a common feature of paediatric pre-B acute lymphoblastic leukaemia

QR Code

Hypomethylation of the CTGF gene locus is a common feature of paediatric pre-B acute lymphoblastic leukaemia

The connective tissue growth factor gene (CTGF) is aberrantly expressed in 75% of precursor B-cell acute lymphoblastic leukaemias (pre-B ALL) and is associated with poor outcome. We identified consistent hypomethylation of the CTGF locus in primary pre-B ALL specimens regardless of CTGF expression....

Full description

Bibliographic Details
Main Authors:	Welch, Mathew, Greene, W., Kees, U.
Format:	Journal Article
Published:	Blackwell Science Ltd 2013
Subjects:	bisulfite sequencing pre-B ALL Leukaemia DNA methylation
Online Access:	http://hdl.handle.net/20.500.11937/28646

Similar Items

Aging of preleukemic thymocytes drives CpG island hypermethylation in T-cell acute lymphoblastic leukemia.
by: Roels, Juliette, et al.
Published: (2020)

Identifying the optimal donor for natural killer cell adoptive therapy to treat paediatric B- and T-cell acute lymphoblastic leukaemia.
by: Foley, Bree, et al.
Published: (2020)

Targeting dormancy in acute myeloid leukaemia
by: Doolan, Lara
Published: (2023)

The epidemiology of leukaemia in the UK
by: Bhayat, Fatima
Published: (2010)

Molecular mechanism underlying aberrant expression of the connective tissue growth factor in paediatric pre-B cell acute lymphoblastic leukemia
by: Welch, Mathew D.
Published: (2011)

Nucleotide methylation and neurocognitive phenotypes
by: Flitton, Miles
Published: (2018)

Poor functional antibody responses are present in nearly all patients with chronic lymphocytic leukaemia, irrespective of total IgG concentration, and are associated with increased risk of infection
by: Parry, Helen Marie, et al.
Published: (2015)

Assessment of DNA damage and DNA damage response and repair in dormancy-enriched leukemia cells
by: Aldosari, Sahar
Published: (2017)

Is gibbon ape leukaemia virus still a threat?
by: Brown, Katherine, et al.
Published: (2016)

Evidence for a Retroviral Insertion in TRPM1 as the Cause of Congenital Stationary Night Blindness and Leopard Complex Spotting in the Horse
by: Bellone, Rebecca, et al.
Published: (2013)

Altered DNA methylation is associated with aberrant gene expression in parenchymal but not airway fibroblasts isolated from individuals with COPD
by: Clifford, Rachel L., et al.
Published: (2018)

Exploiting the reactive oxygen species imbalance in high-risk paediatric acute lymphoblastic leukaemia through auranofin.
by: Karsa, Mawar, et al.
Published: (2021)

A DEMETER-like DNA demethylase protein governs tomato fruit ripening
by: Liu, Rui E., et al.
Published: (2015)

Global DNA methylation profiling of manganese-exposed human neuroblastoma SH-SY5Y cells reveals epigenetic alterations in Parkinson’s disease-associated genes
by: Tarale, Prashant, et al.
Published: (2016)

Generation and characterisation of a tomato epigenetic recombinant inbred line (epiRIL) population
by: Kuswandi, Paramita Cahyaningrum
Published: (2019)

Genome-wide nucleosome map and cytosine methylation levels of an ancient human genome
by: Pedersen, J., et al.
Published: (2014)

Assessing DNA methylation epialleles for human cognitive dysfunction and brain disease
by: Rielly, Nicholas Jude
Published: (2020)

Investigating the potential role of DNA (hydroxy)methylation in the control of post-stroke axon growth
by: Wallis, Marcus
Published: (2020)

DNA methylation profiling of synovial fluid FLS in rheumatoid arthritis reveals changes common with tissue-derived FLS
by: Glossop, John R., et al.
Published: (2015)

Early lineage switch from T-acute lymphoblastic leukaemia to common B-all.
by: Hafiza, A, et al.
Published: (2011)

Mutational signatures in esophageal adenocarcinoma define etiologically distinct subgroups with therapeutic relevance
by: Secrier, Maria, et al.
Published: (2016)

Genome-wide methylation analysis identifies genes silenced in non-seminoma cell lines
by: Noor, Dzul Azri Mohamed, et al.
Published: (2016)

In utero exposure to cigarette chemicals induces sex-specific disruption of one-carbon metabolism and DNA methylation in the human fetal liver
by: Drake, Amanda J., et al.
Published: (2015)

Studying relationship between increased 5-methylcytosine oxidation and expression of cancer stem cell markers in glioblastoma cell lines
by: Wijeyagumar, Vithusha
Published: (2018)

Aberrant DNA methylation and its regulation of gene expression in airway smooth muscle cells of individuals with asthma
by: Clifford, Rachel Louise
Published: (2023)

Structure-function correlation and biophysical analysis of a novel 3D in vitro leukaemia model
by: James, Jenna
Published: (2021)

Association between hypermethylation of DNA repetitive elements in white blood cell DNA and pancreatic cancer
by: Neale, R., et al.
Published: (2014)

Influence of cryopreservation on the cytosine methlation state of potato genomic DNA
by: Kaczmarczyk, Anja, et al.
Published: (2010)

Targeting HOXA in engineered iPSCs and pre-clinical leukaemia models
by: Abuhantash, Mays
Published: (2023)

A phase 2 trial of decreasing tyrosine kinase inhibitor dose in chronic myeloid leukaemia patients with stable major molecular response: data from the British DESTINY study
by: Clark, Richard E., et al.
Published: (2017)

Treatment outcome of children with acute lymphoblastic leukaemia in HUSM
by: Nik Nasiruddin, Nik Leh
Published: (2007)

The Children’s Perceived Locus of Causality Scale for Physical Education
by: Pannekoek, Linda, et al.
Published: (2014)

DNA damage response and anti-apoptotic proteins expression in NPMc+ mutated cells in acute myeloid leukaemia
by: Qutob, Haitham
Published: (2014)

Integrated analysis of the molecular action of Vorinostat identifies epi-sensitised targets for combination therapy
by: Hay, Jodie F., et al.
Published: (2017)

Inhalation of diesel exhaust and allergen alters human bronchial epithelium DNA methylation
by: Clifford, Rachel L., et al.
Published: (2017)

Investigating the regulation of DNA and RNA modifications in neurocognitive diseases
by: Perez Grovas Saltijeral, Adriana
Published: (2025)

Design and development of DNA biosensors based on silver nanoclusters and hybridisation chain reaction
by: Wong, Zheng Wei
Published: (2023)

Considerations for the development of a reference method for sequencing of haploid DNA--an opinion paper on behalf of the IFCC Committee on Molecular Diagnostics, International Federation of Clinical Chemistry and Laboratory Medicine.
by: Rousseau, F., et al.
Published: (2009)

Efflux genes and active efflux activity detection in of methicillin-resistant Staphylococcus aureus (MRSA).
by: Saiful, Azmi Johari, et al.
Published: (2008)

Therapeutic targeting of the leukaemia microenvironment
by: Kuek, V., et al.
Published: (2021)

Cannot write session to /tmp/vufind_sessions/sess_utcb8ui1uncmpfu32esj70ja64