Hypomethylation of the CTGF gene locus is a common feature of paediatric pre-B acute lymphoblastic leukaemia

Hypomethylation of the CTGF gene locus is a common feature of paediatric pre-B acute lymphoblastic leukaemia

The connective tissue growth factor gene (CTGF) is aberrantly expressed in 75% of precursor B-cell acute lymphoblastic leukaemias (pre-B ALL) and is associated with poor outcome. We identified consistent hypomethylation of the CTGF locus in primary pre-B ALL specimens regardless of CTGF expression....

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Bibliographic Details
Main Authors: Welch, Mathew, Greene, W., Kees, U.
Format: Journal Article
Published: Blackwell Science Ltd 2013
Subjects:
bisulfite sequencing
pre-B ALL
Leukaemia
DNA methylation
Online Access:http://hdl.handle.net/20.500.11937/28646

Internet

http://hdl.handle.net/20.500.11937/28646

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